GLP1R
GLP-1R，即胰高血糖素樣肽-1受體，別名GLP-1 recepto、GLP-1-R、GLP-1R，它屬于B1類G蛋白偶聯(lián)受體（GPCR），是調(diào)節(jié)體內(nèi)血糖水平的重要受體，被廣泛認(rèn)為是2型糖尿病和肥胖癥的治療靶點(diǎn)。GLP-1R激動(dòng)劑通過模擬天然GLP-1的作用，以葡萄糖濃度依賴的方式增強(qiáng)胰島素分泌、抑制胰高血糖素分泌，并能夠延緩胃排空，減少食物攝入，降低血糖。GLP-1R的信號(hào)傳導(dǎo)主要通過與多種G蛋白（如Gαs、Gαi、Gαo和Gαq/11）偶聯(lián)來實(shí)現(xiàn)，激活不同的細(xì)胞內(nèi)信號(hào)通路，如cAMP/PKA途徑，進(jìn)而提高葡萄糖感受性，刺激胰島素的分泌。GLP-1R的生物學(xué)意義主要體現(xiàn)在其對(duì)維持血糖穩(wěn)態(tài)的貢獻(xiàn)上。它不僅在降低血糖方面發(fā)揮作用，還具有減重、降壓和改善血脂譜等多重效應(yīng)。此外，GLP-1R激動(dòng)劑的研究和開發(fā)已成為糖尿病和肥胖治療領(lǐng)域的熱點(diǎn)，全球市場(chǎng)規(guī)模巨大且持續(xù)增長(zhǎng)。隨著對(duì)GLP-1R結(jié)構(gòu)和功能認(rèn)識(shí)的深入，新型激動(dòng)劑的設(shè)計(jì)與開發(fā)不斷取得進(jìn)展，為治療相關(guān)代謝性疾病提供了新的思路和希望。
熱銷產(chǎn)品
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) (CSB-MP009514HUb1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
GLP1R monoclonal antibody (CSB-RA009514MA1HU)
驗(yàn)證數(shù)據(jù)
The Binding Activity of GLP1R with anti-GLP1R antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R(CSB-MP009514HUb1) at 2 μg/mL can bind Anti-GLP1R recombinant antibody, the EC50 is 54.54-94.23 ng/mL.
Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
GLP1R Antibodies
GLP1R for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009514LD01HU | GLP1R Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA009514YA01HU | GLP1R Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA009514YB01HU | GLP1R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009514YD01HU | GLP1R Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA009514LA01HU | GLP1R Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA002699 | GLP1R Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA183226 | GLP1R Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA009514MA1HU | GLP1R monoclonal antibody | Human | ELISA, FC |
GLP1R for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009514HA01MO | Glp1r Antibody | Mouse | ELISA, WB |
| CSB-PA009514HB01MO | Glp1r Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA009514HC01MO | Glp1r Antibody, FITC conjugated | Mouse | |
| CSB-PA009514HD01MO | Glp1r Antibody, Biotin conjugated | Mouse | ELISA |
GLP1R Proteins
GLP1R Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Yeast |
| CSB-CF009514RA | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r) | in vitro E.coli expression system |
| CSB-EP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | E.coli |
| CSB-BP009514RA1 | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Baculovirus |
| CSB-YP009514RA | Recombinant Rat Glucagon-like peptide 1 receptor (Glp1r), partial | Yeast |
GLP1R Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009514MO1 CSB-BP009514MO1 CSB-MP009514MO1 CSB-EP009514MO1-B |
Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009514MO | Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r) | in vitro E.coli expression system |
| CSB-EP009514MO1 | Recombinant Mouse Glucagon-like peptide 1 receptor (Glp1r), partial | E.coli |
GLP1R Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | E.coli |
| CSB-YP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | Yeast |
| CSB-MP009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | Mammalian cell |
| CSB-CF009514HU | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R) | in vitro E.coli expression system |
| CSB-CF009514HU(A4) | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R) | in vitro E.coli expression system |
| CSB-MP009514HU(A4) | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R)-VLPs | Mammalian cell |
| CSB-MP009514HUb1 | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) | Mammalian cell |
| CSB-EP009514HUd7 | Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial | E.coli |
GLP1R Proteins for Homo sapiens(Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP009514HU | Recombinant human Glucagon-like peptide 1 receptor | Baculovirus |
GLP1R ELISA Kit
GLP1R ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL009514MO | Mouse Glucagon-like peptide 1 receptor(GLP1R) ELISA kit | serum, plasma, tissue homogenates | 0.11 ng/ml |
