FOLR1

FOLR1（葉酸受體1）是一種成人葉酸受體，也稱為葉酸結(jié)合蛋白（FBP），由FOLR1基因編碼。這種膜結(jié)合糖蛋白對葉酸和幾種還原葉酸衍生物具有高親和力，主要功能是介導(dǎo)5-甲基四氫葉酸的細(xì)胞內(nèi)運(yùn)輸，對細(xì)胞生長和增殖至關(guān)重要。FOLR1的結(jié)構(gòu)包括跨膜結(jié)構(gòu)域，并存在膜結(jié)合和可溶性兩種形式。除了在葉酸轉(zhuǎn)運(yùn)中的基本作用外，F(xiàn)OLR1還參與了多種信號通路，包括JAK-STAT3、ERK1/2信號通路，并可能作為轉(zhuǎn)錄因子參與基因表達(dá)調(diào)控。FOLR1在Wnt和ERK信號通路中發(fā)揮作用，通過增加活性β-catenin、磷酸化ERK以及Wnt和ERK調(diào)控基因的表達(dá)。此外，F(xiàn)OLR1還可能參與Wnt和TGFβ信號通路。 FOLR1的異常表達(dá)與多種癌癥的發(fā)生、發(fā)展密切相關(guān)，其在腫瘤細(xì)胞中的高表達(dá)通常與癌癥進(jìn)展加快和患者預(yù)后不良有關(guān)。因此，F(xiàn)OLR1不僅是癌癥治療研究中的潛在靶點(diǎn)，而且在葉酸受體靶向治療領(lǐng)域具有重要的應(yīng)用前景。

熱銷產(chǎn)品

Recombinant Human Folate receptor alpha(FOLR1),partial (Active) (CSB-MP008784HU1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized human FOLR1 at 2 μg/ml can bind Anti-FOLR1 recombinant antibody(CSB-RA008784MA1HU). The EC₅₀ is 6.893-7.883 ng/mL.

The purity of FOLR1 was greater than 95% as determined by SEC-HPLC

Recombinant Macaca fascicularis Folate receptor alpha(FOLR1),partial (Active) (CSB-MP5002MOV)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus FOLR1 at 2 μg/ml can bind Anti-FOLR1 recombinant antibody(CSB-RA008784MA1HU). The EC₅₀ is 2.900-3.544 ng/mL.

FOLR1 Antibody

FOLR1 Protein

FOLR1 ELISA Kit

FOLR1 Antibodies

FOLR1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA008378	FOLR1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA008784LA01HU	FOLR1 Antibody	Human	ELISA, IHC, IF
CSB-PA008784LB01HU	FOLR1 Antibody, HRP conjugated	Human	ELISA
CSB-PA008784LC01HU	FOLR1 Antibody, FITC conjugated	Human
CSB-PA008784LD01HU	FOLR1 Antibody, Biotin conjugated	Human	ELISA

FOLR1 Proteins

FOLR1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008784HU CSB-EP008784HU CSB-BP008784HU CSB-MP008784HU CSB-EP008784HU-B	Recombinant Human Folate receptor alpha (FOLR1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FOLR1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008784MO CSB-EP008784MO CSB-BP008784MO CSB-MP008784MO CSB-EP008784MO-B	Recombinant Mouse Folate receptor alpha (Folr1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

FOLR1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP008784BO CSB-EP008784BO CSB-BP008784BO CSB-MP008784BO CSB-EP008784BO-B	Recombinant Bovine Folate receptor alpha (FOLR1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli