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CXCR4

CXCR4:G蛋白耦聯(lián)受體(GPCR)家族,再出腫瘤免疫治療新藥!

趨化因子受體(C X C chemokine receptor 4,CXCR4)是一個(gè)具有7次跨膜結構的G蛋白耦聯(lián)受體。CXCR4作為GPCR家族中的一員,GPCR的超家族群已經(jīng)被證明是許多藥物的藥理作用靶點(diǎn)。CXCR4在體內大部分組織和器官上都有表達,包括骨髓、臍血和動(dòng)員的外周血來(lái)源的細胞表面,以及多種非造血干細胞表面表達。近年來(lái)研究發(fā)現,腫瘤細胞轉移到特定器官是不同器官通過(guò)趨化作用吸引特定類(lèi)型腫瘤細胞歸巢的結果。在眾多的趨化因子受體中,CXCR4在許多腫瘤中都存在表達增強。目前的研究表明,與趨化因子受體CXCR4相關(guān)的癌癥超過(guò)23種,它還能促進(jìn)血管生成,細胞的轉移、生長(cháng)或生存。此外,還參與HIV病毒感染。這些生物學(xué)功能決定了CXCR4靶向藥可用于腫瘤、造血干細胞動(dòng)員、HIV等疾病的治療。

CUSABIO-哺乳包膜VLPs平臺成功開(kāi)發(fā)CXCR4全長(cháng)膜蛋白(7次跨膜),展示了完整生物活性。

熱銷(xiāo)產(chǎn)品

Recombinant Human C-X-C chemokine receptor type 4(CXCR4)-VLPs (Active)(CSB-MP006254HU(F1))

驗證數據

High Specificity Validated by Western Blot (WB)

CSB-MP006254HU(F1) is detected by Mouse anti-6*His monoclonal antibody.

Excellent Bioactivity Validated by Functional ELISA

Immobilized Human CXCR4 at 10 μg/ml can bind Anti-CXCR4 recombinant antibody (CSB-RA006254MA01HU), the EC50 is 101.7-253.6 ng/mL.

CXCR4 Antibodies

CXCR4 for Homo sapiens (Human)

CXCR4 Proteins

CXCR4 Proteins for Mus musculus (Mouse)

CXCR4 Proteins for Macaca mulatta (Rhesus macaque)

CXCR4 Proteins for Bos taurus (Bovine)

CXCR4 Proteins for Felis catus (Cat) (Felis silvestris catus)

CXCR4 Proteins for Rattus norvegicus (Rat)

CXCR4 Proteins for Papio anubis (Olive baboon)

CXCR4 Proteins for Pan troglodytes (Chimpanzee)

CXCR4 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

CXCR4 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CXCR4 Proteins for Ovis aries (Sheep)

CXCR4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CXCR4 Proteins for Sus scrofa (Pig)

CXCR4 Proteins for Tupaia chinensis (Chinese tree shrew)

CXCR4 Proteins for Saimiri sciureus (Common squirrel monkey)

CXCR4 Proteins for Callithrix jacchus (White-tufted-ear marmoset)

CXCR4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

CXCR4 Proteins for Homo sapiens (Human)

CXCR4 Proteins for Homo sapiens (Human)

CXCR4 ELISA Kit

CXCR4 ELISA Kit for Homo sapiens (Human)

CXCR4 ELISA Kit for Rattus norvegicus (Rat)