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CD274

PD-1——重要的免疫檢查點(diǎn)

CD274(PDCD1配體1,又稱(chēng)PD-L1或B7-H1)是重要的免疫檢查點(diǎn)蛋白。PD-L1作為PD-1的配體之一,PD-L1能夠與PD-1結合,抑制T細胞增殖以及細胞因子分泌,負調控淋巴細胞的激活。PD-L1除了會(huì )表達在腫瘤表面,參與免疫逃逸,還會(huì )在IFN-γ刺激下,表達在抗原提呈細胞(DC細胞、巨噬細胞等),以及血管內皮細胞的表面。大量研究發(fā)現PD-1和PD-L1信號通路在感染免疫、腫瘤免疫、移植免疫中起著(zhù)重要作用。尤其在腫瘤中,PD-L1與PD-1的結合,可誘導T細胞凋亡、失能、耗竭,進(jìn)而抑制腫瘤抗原特異性CD8+T細胞的激活、增殖和抗腫瘤功能,實(shí)現腫瘤免疫逃逸,然而阻斷PD-1/PD-L1通路可以恢復免疫系統對腫瘤細胞的殺傷作用。因此,靶向PD-1/PD-L1信號通路成為治療腫瘤的研究熱點(diǎn)。

Recombinant Human CD274 活性蛋白實(shí)驗驗證數據

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m,antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL.


CD274 Antibodies

CD274 for Homo sapiens (Human)

CD274 Proteins

CD274 Proteins for Homo sapiens (Human)

CD274 Proteins for Mus musculus (Mouse)

CD274 ELISA Kit

CD274 ELISA Kit for Homo sapiens (Human)

CD274 ELISA Kit for Mus musculus (Mouse)